Information about GERD Symptoms, Diagnosis, Treatment options, and GERD Medication
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Irritable Bowel Syndrome (IBS)


 Dilated Intercellular Space (DIS) in GERD

Multiple recent studies have shown that the earliest changes in esophageal mucosa in patients suffering from frequent heartburn is Dilated Intercellular Space.

Transmission electron microscopy of esophageal biopsy specimen in GERD patients reveals:

  1. Irrespective of whether or not a pH study is positive, all GERD patients who respond to PPIs ( Erosive GERD and NERD ) have dilated intercellular space (DIS) at least twice normal in the superficial squamous epithelium of distal esophagus

  2. DIS resolves with effective GERD therapy in essentially every instance



A & C represent DIS in patients with GERD
B & D normalized Intercellular spaces in the same patients after 3 month treatment with PPI







         This is an educational site created by M. Farivar, M.D. The information provided is the author's opinion based on years of clinical experience and research.  You are advised to consult your own physician about the applicability of this information to your particular needs.  Also, keep in mind that symptom response to therapy does not preclude the presence of more serious conditions. 

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