|
Dilated Intercellular Space (DIS) in
GERD
Multiple recent studies have shown that the earliest changes in esophageal
mucosa in patients suffering from frequent heartburn is Dilated Intercellular
Space.
Transmission electron microscopy
of esophageal biopsy specimen in GERD patients
reveals:
Irrespective of whether
or not a pH study is positive, all GERD patients who respond to PPIs (
Erosive GERD and NERD ) have dilated intercellular space (DIS) at least
twice normal in the superficial squamous epithelium of distal esophagus
- DIS resolves with effective GERD therapy in
essentially every instance
A & C represent DIS in
patients with GERD
B & D normalized Intercellular spaces in the same patients after 3 month
treatment with PPI
|
